Effect of laparoscopic repair on acute perforation of gastroduodenal ulcer and its influences on immune function and oxidative stress level
Objective To investigate the effect of laparoscopic repair on acute perforation of gastroduodenal ulcer and its influences on immune function and oxidative stress level.Methods A total of 68 patients with acute perforation of gastroduodenal ulcer admitted in our hospital from January 2020 to January 2023 were selected and divided into control group(34 cases)and observation group(34 cases)by random number table method.The control group was treated with traditional open surgery,and the observation group was treated with laparoscopic repair.The surgical effects of the two groups were compared.Results The operation time,hospitalization time,intestinal function recovery time and anal exhaust time were shorter than those of the control group,and the intraoperative blood loss was less than that of the control group(P<0.05).After treatment,the levels of pepsinogen I(PGI)and gastrin-17(G-17)in the two groups decreased,and those in the observation group were lower than the control group(P<0.05).After treatment,CD3+,CD4+and CD4+/CD8+in the observation group were higher than those in the control group,and CD8+was lower than that in the control group(P<0.05).After treatment,the levels of cortisol(Cor),norepinephrine(NE)and angiopoietin-Ⅱ(Ang-Ⅱ)in the observation group were lower than those in the control group(P<0.05).The total incidence of complications in the observation group was 5.88%,which was lower than 26.47%in the control group(P<0.05).Conclusion Laparoscopic repair has a significant effect on patients with acute perforation of gastroduodenal ulcer,which can promote postoperative recovery,reduce oxidative stress response,improve immune function,and has fewer postoperative complications.
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