Effects of ultrasound-guided serratus anterior plane block combined with general anesthesia on anesthetic dosage and stress response in patients undergoing laparoscopic radical nephrectomy
Objective To investigate the effects of ultrasound-guided serratus anterior plane block combined with general anesthesia on anesthetic dosage and stress response in patients undergoing laparoscopic radical nephrectomy.Methods A total of 80 patients undergoing laparoscopic radical nephrectomy in our hospital from January 2020 to January 2022 were selected and divided into control group and observation group by random number table method,with 40 cases in each group.The control group was adopted with ultrasound-guided quadratus lumborum block combined with general anesthesia,and the observation group was adopted with ultrasound-guided serratus anterior plane block combined with general anesthesia.The anesthetic effects of the two groups were compared.Results The operation time of nerve block and onset time of nerve block in the observation group were shorter than those in the control group,dosage of sufentanil,dosage of propofol and pressing times of analgesia pump were less than those in the control group,and the differences were statistically significant(P<0.05).At 2,6,12 and 48 h after operation,the Ramsay Sedation Scale(RSS)score of the two groups showed a gradually increasing trend,and the difference was statistically significant(P<0.05);at 2,6 and 12 h after operation,the RSS score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).At 1 and 3 d after operation,the score of Mini-Mental State Examination(MMSE)in the two groups was lower than that before operation(P<0.05);at 3 and 7 d after operation,the MMSE score of the two groups was higher than that at 1 d after operation,and the difference was statistically significant(P<0.05);at 3 d after operation,the MMSE score of the observation group was higher than that of the control group(P<0.05).After operation,the malondialdehyde(MDA)level of the observation group was lower than that of the control group,and the superoxide dismutase(SOD)level was higher than that of the control group,and the differences were statistically significant(P<0.05).Conclusion Ultrasound-guided serratus anterior plane block combined with general anesthesia can improve the anesthetic effect of patients undergoing laparoscopic radical nephrectomy,reduce the dosage of anesthetic drugs,and alleviate the impact on postoperative cognitive function and oxidative stress response.
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