Analysis of risk factors and prognosis of moderate to severe bronchopulmonary dysplasia in very low birth weight infants
Objective To analyze the risk factors and prognosis of moderate to severe bronchopulmonary dysplasia(BPD)in very low birth weight infants.Methods A total of 142 very low birth weight infants admitted in hospital from June 2018 to June 2022 were retrospectively selected,5 deaths were excluded,6 cases were transferred and discharged automatically,and 131 cases were finally included.According to the 2019 Neonatal Research Network(NRN)standard,grade Ⅰ BPD was included in mild group,and grade Ⅱand grade Ⅲ BPD were included in moderate to severe group.The clinical data of children and pregnant women were collected,and the risk factors of moderate to severe BPD in very low birth weight infants were analyzed by binary Logistic regression.Results Among the 131 children,96 cases were in the mild group and 35 cases were in the moderate to severe group.The proportions of gestational age≤28 weeks,1 min Apgar score≤3 points,mechanical ventilation≥7 d,secondary admission due to respiratory system disease in the moderate to severe group were higher than those in the mild group,and the non-invasive ventilation time and total enteral nutrition time were longer than those in the mild group(P<0.05).The binary Logistic regression analysis results showed that gestational age≤28 weeks,mechanical ventilation≥7 d and long non-invasive ventilation time were independent risk factors for moderate to severe BPD in very low birth weight infants(P<0.05).Conclusion Gestational age≤28 weeks,mechanical ventilation≥7 d and long non-invasive ventilation time are independent risk factors for moderate to severe BPD in very low birth weight infants.Therefore,for very low birth weight infants with gestational age≤32 weeks,prolonging intrauterine development time and reducing mechanical ventilation time as much as possible after birth can reduce the probability of moderate to severe BPD and improve the prognosis of children to a certain extent.
moderate to severebronchopulmonary dysplasiavery low birth weight infant
万方数据
维普
