Meta-analysis of risk factors for rheumatoid arthritis related interstitial lung disease
Objective To systematically evaluate the risk factors of rheumatoid arthritis related interstitial lung disease(RA-ILD)by Meta-analysis.Methods The Cochrane Library,PubMed,Embase,Web of Science,Chinese Biomedical Literature Database(CBM),China National Knowledge Infrastructure(CNKI)and Wanfang science and technology journal full-text database were searched by computer to collect all studies related to RA-ILD risk factors,and the retrieval time limit was from the establishment of the database to January 2023.The Newcastle-Ottawa Scale(NOS)was used to evaluate the quality of the included studies.The relevant data were extracted independently by two authors,and the fixed or random effect model was used to combine the effect size.Meta-analysis,subgroup analysis and sensitivity analysis were performed by R software;Egger's test was used to evaluate publication bias using Stata12.0 software.Results A total of 15 articles were included.The results of Meta-analysis showed that male[odds ratio(OR)=1.78,95%CI(1.39,2.27),P<0.001],older age[mean difference(MD)=5.26,95%CI(2.67,7.84),P<0.001],longer course of rheumatoid arthritis(RA)[MD=1.43,95%CI(0.34,2.53),P=0.01],older age at onset of RA[MD=5.52,95%CI(1.78,9.25),P=0.004],smoking[OR=1.59,95%CI(1.11,2.29),P=0.01],positive rheumatoid factor(RF)[OR=1.74,95%CI(1.46,2.07),P<0.001],positive anti-cyclic citrullinated peptide(CCP)antibody[OR=1.48,95%CI(1.22,1.80),P<0.001]were risk factors for RA-ILD.Conclusion Male,old age,long course of RA,old age at onset of RA,smoking,positive RF and positive anti-CCP antibody were risk factors for RA-ILD.
万方数据
维普
