Effect of salmeterol xinafoate and fluticasone propionate combined with invasive mechanical ventilation-nasal high flow oxygen therapy sequential therapy on chronic obstructive pulmonary disease with respiratory failure and its influences on oxygen metabol
Objective To analyze the effect of salmeterol xinafoate and fluticasone propionate combined with invasive mechanical ventilation-nasal high flow oxygen therapy sequential therapy on chronic obstructive pulmonary disease with respiratory failure.Methods A total of 120 patients with chronic obstructive pulmonary disease with respiratory failure admitted from February 2019 to March 2021 were selected as the research objects and randomly divided into control group and observation group,with 60 cases in each group.The control group was treated with invasive mechanical ventilation-nasal high flow oxygen therapy sequential therapy,and the observation group was treated with salmeterol xinafoate and fluticasone propionate on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the maximal oxygen consumption(VO2max),oxygen extraction ratio(O2ER)and arterial partial pressure of carbon dioxide(PaCO2)in the observation group were lower than those in the control group,and the arterial oxygen content(CaO2)was higher than that in the control group(P<0.05).After treatment,the levels of interleukin-18(IL-18),procalcitonin(PCT),C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)in the observation group were lower than those in the control group(P<0.05).Conclusion Salmeterol xinafoate and fluticasone propionate combined with invasive mechanical ventilation-nasal high flow oxygen therapy sequential therapy in the treatment of patients with chronic obstructive pulmonary disease with respiratory failure can not only improve the clinical treatment effect,but also improve oxygen metabolism,inhibit inflammatory response.It has a positive effect on the recovery of lung function and is worthy of promotion.
salmeterol xinafoate and fluticasone propionateinvasive mechanical ventilation-nasal high flow oxygen therapy sequential therapychronic obstructive pulmonary diseaserespiratory failure
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