Effect of holmium laser lithotripsy under two-stage electronic flexible ureteroscope in the treatment of upper ureteral calculi and renal calculi and its influence on the success rate of lithotripsy
Objective To explore the effect of holmium laser lithotripsy under two-stage electronic flexible ureteroscope in the treatment of upper ureteral calculi and renal calculi and its influence on the success rate of lithotripsy.Methods A total of 68 patients with upper ureteral calculi complicated with renal calculi admitted from December 2019 to December 2021 were selected as the research objects.According to the difference of treatment plan,the patients were divided into control group and study group,with 34 cases in each group.The control group was treated with minimally invasive percutaneous nephrolithotripsy(PCNL),and the study group was treated with holmium laser lithotripsy under two-stage electronic flexible ureteroscope.The operation related indexes,renal injury indexes and immune function indexes were compared between the two groups.Results The operation time,postoperative hospital stay and postoperative ambulation time of the study group were shorter than those of the control group,the intraoperative blood loss was less than that of the control group,the success rate of lithotripsy was higher than that of the control group,and the differences were statistically significant(P<0.05).At 3 d after operation,the levels of kidney injury molecule-1(KIM-1),blood urea nitrogen(BUN),serum creatinine(Scr)and β2-microglobulin(β2-MG)in the two groups increased,but those in the study group were lower than the control group,and the differences were statistically significant(P<0.05).At 3 d after operation,the CD3+,CD4+and CD4+/CD8+in the two groups were lower than those before operation,and the CD8+was higher than that before operation,the differences were statistically significant(P<0.05);at 3 d after operation,the CD3+,CD4+and CD4+/CD8+in the study group were higher than those in the control group,and the CD8+was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion Holmium laser lithotripsy under two-stage electronic flexible ureteroscope has a high success rate of lithotripsy in the treatment of upper ureteral calculi and renal calculi,and has little effect on renal function and immune function,which has clinical application value.
万方数据
维普
