Influences of dexmedetomidine pretreatment combined with transversus abdominis plane block anesthesia on anesthesia effect and cognitive function in patients undergoing laparoscopic radical resection of colorectal cancer
Objective To investigate the influences of dexmedetomidine pretreatment combined with transversus abdominis plane block anesthesia on anesthesia effect and cognitive function in patients undergoing laparoscopic radical resection of colorectal cancer.Methods A total of 120 patients undergoing laparoscopic radical resection of colorectal cancer in our hospital from October 2021 to October 2022 were selected and divided into control group and observation group by random number table method,with 60 cases in each group.The control group was treated with transversus abdominis plane block anesthesia,and the observation group was treated with dexmedetomidine pretreatment+transversus abdominis plane block anesthesia.The anesthetic effects of the two groups were compared.Results The onset time and the time to reach the highest plane of sensory block and motor block in the observation group were shorter than those in the control group,and the duration was longer than that in the control group(P<0.05).At 10 min of operation(T1)and the end of operation(T2),the mean arterial pressure(MAP)and blood oxygen saturation(SpO2)in the observation group were higher than those in the control group(P<0.05).At 12 and 24 h after operation,the scores of Mini-Mental State Examination(MMSE)and Montreal Cognitive Assessment Scale(MoCA)in the observation group were higher than those in the control group(P<0.05).Conclusion Dexmedetomidine pretreatment combined with transversus abdominis plane block anesthesia can improve the anesthetic effect of patients undergoing laparoscopic radical resection of colorectal cancer,maintain hemodynamic stability,and reduce the impact on postoperative cognitive function.
demetomidinetransversus abdominis plane block anesthesiaradical resection of colorectal cancer
万方数据
维普
