Efficacy and safety of methylprednisolone sodium succinate in the treatment of patients with severe mycoplasma pneumonia
Objective To analyze the efficacy and safety of methylprednisolone sodium succinate in the treatment of patients with severe mycoplasma pneumonia.Methods A total of 98 patients with severe mycoplasma pneumonia admitted in our hospital from January to December 2021 were selected as the research objects,the patients were divided into conventional group(49 cases,routine treatment)and observation group(49 cases,routine treatment+methylprednisolone sodium succinate treatment)by random number table method.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the conventional group(P<0.05).The fever disappearance time,cough disappearance time,lung rale disappearance time,X-ray lung inflammation shadow disappearance time and total hospitalization time of the observation group were shorter than those of the conventional group(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),hypersensitive C-reactive protein(hs-CRP)and interleukin-17(IL-17)in the observation group were lower than those in the conventional group(P<0.05).After treatment,the forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),FEV1/FVC,maximal vital capacity(VCmax)and maximal voluntary ventilation(MVV)in the observation group were higher than those in the conventional group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Methylprednisolone sodium succinate in the treatment of patients with severe mycoplasma pneumonia can effectively shorten the recovery time,quickly eliminate inflammatory reactions,improve lung function and ventilation function,and will not increase adverse reactions,can achieve ideal treatment effect.
severe mycoplasma pneumoniamethylprednisolone sodium succinateinflammatory responselung function
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维普
