Effects of different doses of bone cement vertebroplasty on pain response and vertebral function in elderly patients with thoracolumbar fractures
Objective To explore the effects of different doses of bone cement vertebroplasty on pain response and vertebral function in elderly patients with thoracolumbar fractures.Methods A total of 80 elderly patients with thoracolumbar fractures admitted from January 2020 to January 2023 were selected as the research objects and divided into control group and observation group by random number table method,with 40 cases in each group.The control group was treated with conventional dose of bone cement vertebroplasty,and the observation group was treated with high dose of bone cement vertebroplasty.The therapeutic effects of the two groups were compared.Results At 3 d after operation,the levels of substance P(SP),prostaglandin E2(PGE2)and bradykinin(BK)in the observation group were lower than those in the control group(P<0.05).Before and 3 d after operation,there were no significant differences in anterior vertebral compression rate and Cobb angle between the two groups(P>0.05).One month after operation,the level of procollagen type ⅠN-terminal propeptide(PⅠNP)in the observation group was higher than that in the control group,and the level of type Ⅰ collagen carboxy terminal peptide β special sequence(β-CTX)was lower than that in the control group(P<0.05).One month after operation,the levels of interleukin-1(IL-1),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the observation group were lower than those in the control group(P<0.05).Conclusion High dose bone cement vertebroplasty in the treatment of elderly patients with thoracolumbar fractures has less stimulation to pain response,can improve vertebral function and bone metabolism,reduce inflammatory response,which is worthy of promotion.
bone cementvertebroplastythoracolumbar fracturepain responsevertebral function
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维普
