Effect of combined treatment with loratadine and glucocorticoid on respiratory status in children with allergic rhinitis complicated with asthma
Objective To analyze the effect of combined treatment with loratadine and glucocorticoid on respiratory status in children with allergic rhinitis complicated with asthma.Methods A total of 140 children with allergic rhinitis complicated with asthma admitted in our hospital from January 2020 to January 2023 were selected as the research objects.The children were randomly divided into conventional group(70 cases,glucocorticoid treatment)and observation group(70 cases,loratadine and glucocorticoid treatment).The therapeutic effect,inflammatory factors levels,respiratory status indicators and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the conventional group,and the difference was statistically significant(P<0.05).After treatment,the levels of leukotriene B4(LTB4),percentage of eosinophils(EOS%),intercellular cell adhesion molecule-1(ICAM-1),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and interleukin-6(IL-6)in the observation group were significantly lower than those in the conventional group,and the differences were statistically significant(P<0.05).After treatment,the tidal volume per kilogram of body weight(VT/kg),peak expiratory flow(PEF),ratio of the time to reach peak tidal expiratiry flow to total expiratory time(TPTEF/TE),maximal vital capacity(VCmax)and maximal voluntary ventilation(MVV)in the observation group were significantly higher than those in the conventional group,and the respiratory rate(RR)was significantly lower than that in the conventional group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Loratadine combined with glucocorticoid in the treatment of children with allergic rhinitis complicated with asthma can achieve ideal effect.
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