Effect of macular grid laser photocoagulation combined with intravitreal injection of ranibizumab and triamcinolone acetonide in the treatment of retinal vein occlusion macular edema and its influences on retinal blood flow parameters
Objective To explore the effect of macular grid laser photocoagulation combined with intravitreal injection of ranibizumab and triamcinolone acetonide in the treatment of retinal vein occlusion macular edema.Methods A total of 300 patients with retinal vein occlusion macular edema admitted in our hospital from January 2019 to October 2022 were selected as the research objects,and the patients were divided into control group and observation group by random number table method,with 150 cases in each group.The control group was treated with macular grid laser photocoagulation+triamcinolone acetonide,and the observation group was treated with intravitreal injection of ranibizumab on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After 3 months of treatment,the peak systolic velocity(PSV)and end diastolic velocity(EDV)of the central retina in the observation group were higher than those in the control group(P<0.05).At discharge,the levels of connective tissue growth factor(CTGF),platelet derived growth factor-C(PDGF-C)and vascular endothelial growth factor(VEGF)in the observation group were lower than those in the control group(P<0.05).After 3 months of treatment,the trefoil aberration,total higher-order aberration,spherical aberration and coma aberration of the observation group were better than those of the control group(P<0.05).Conclusion Macular grid laser photocoagulation combined with intravitreal injection of ranibizumab and triamcinolone acetonide is effective in the treatment of retinal vein occlusion macular edema,it can regulate the expression of growth factors,improve retinal blood flow pa-rameters and visual quality,which is worthy of promotion.
万方数据
维普
