Relationship between serum homocysteine,cystatin C and uric acid levels and the degree of carotid atherosclerosis in patients with H-type hypertension
Objective To analyze the relationship between serum homocysteine(Hcy),cystatin C(CysC)and uric acid(UA)levels and the degree of carotid atherosclerosis in patients with H-type hypertension.Methods A total of 200 patients with H-type hypertension admitted from February 2021 to February 2023 were selected as observation group,and 200 patients with essential hypertension who underwent routine examination during the same period were selected as control group.The levels of serum Hcy,CysC and UA in each group were compared,and their relationship with the degree of carotid atherosclerosis was analyzed.Results The levels of serum Hcy,CysC and UA in the observation group were higher than those in the control group,and the carotid intima-media thickness was greater than that in the control group,and the differences were statistically significant(P<0.05).The levels of serum Hcy,CysC and UA in the normal group were lower than those in the mild-to-moderate thickening group and the severe thickening group,and the differences were statistically significant(P<0.05);the levels of serum Hcy,CysC and UA in the mild-to-moderate thickening group were lower than those in the severe thickening group,and the differences were statistically significant(P<0.05).The levels of serum Hcy,CysC and UA in the non-plaque group were lower than those in the stable plaque group and the unstable plaque group,and the carotid intima-media thickness was smaller than that in the stable plaque group and the unstable plaque group(P<0.05);the levels of serum Hcy,CysC and UA in the stable plaque group were lower than those in the unstable plaque group,and the carotid intima-media thickness was smaller than that in the unstable plaque group(P<0.05).Conclusion The levels of serum Hcy,CysC and UA in patients with H-type hypertension are related to the degree of carotid atherosclerosis,which can provide scientific basis for the evaluation and prognosis of patients with H-type hypertension.
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