Evaluation of regional myocardial function changes in breast cancer patients after chemotherapy by ultrasonic myocardial work
Objective To evaluate the changes of regional myocardial function in patients with breast cancer after chemotherapy by ultrasonic myocardial work.Methods From September 2021 to October 2022,27 female patients with invasive breast cancer who were treated in the oncological surgery department of our hospital were selected as case group.At the same time,30 females who underwent physical examination in the physical examination center of our hospital were selected as control group.Echocardiography was performed in the case group before chemotherapy(T0),after 2 cycles of chemotherapy(T1),and after 4 cycles of chemotherapy(T2)and the control group.The two-dimensional ultrasound parameters,four-dimensional auto quantification of left ventricular volume(4D-LVQ)parameters and left ventricular global longitudinal strain(GLS)parameters were compared between the two groups;the myocardial work"bull's eye diagram"was analyzed.Results There was no significant difference in left ventricular ejection fraction(LVEF)between T1,T2 and T0 in the case group(P＞0.05).The global work index(GWI),global constructive work(GCW),global work efficiency(GWE)and GLS at T2 in the case group were lower than those at T0,while the global wasted work(GWW)was bigger than that at T0(P＜0.05).The basal/middle/apical myocardial work index(MWI-B,MWI-M,MWI-AP)and basal/middle/apical myocardial work efficiency(MWE-B,MWE-M,MWE-AP)at T2 in the case group were lower than those at T0(P＜0.05).The MWI and MWE of the control group and the case group at T0,T1 and T2 showed an increase from the bottom of the heart to the apex of the heart.Conclusion The noninvasive myocardial work is earlier than the volume change.The"bull's eye diagram"of myocardial work can evaluate the local myocardial function of patients with early breast cancer after chemotherapy.
ultrasonic myocardial workfour-dimensional auto quantification of left ventricular volumebreast canceranthracycline drug
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