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冠心病患者冠脉血管钙化的影响因素分析

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目的 分析冠心病患者冠脉血管钙化的影响因素，以期为临床诊疗疾病提供参考。方法 回顾性分析2021年 5 月至2023 年 5 月我院收治的 86 例冠心病患者的临床资料，包括年龄、性别、体质量指数(BMI)、病程、合并疾病、血脂指标[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、骨保护素(OPG)、骨桥蛋白(OPN)、血肌酐(Scr)、血尿酸及血压[收缩压(SBP)、舒张压(DBP)]，分析冠心病患者冠脉血管钙化情况，同时采用多因素Logistic回归分析探讨影响冠心病患者冠脉血管钙化的因素。结果 86 例冠心病患者中，有69 例(80。23%)患者未发生冠脉血管钙化，纳为未发生组;有17例(19。77%)患者发生冠脉血管钙化，纳为发生组。两组的性别构成比、BMI、病程、合并疾病构成比、血脂指标及血压比较，差异无统计学意义(P＞0。05);发生组的年龄、OPG、OPN、Scr及血尿酸水平均高于未发生组，差异具有统计学意义(P＜0。05)。多因素Logistic回归分析显示，年龄、OPG、OPN、Scr及血尿酸是影响冠心病患者冠脉血管钙化的独立危险因素(P＜0。05)。结论 年龄、OPG、OPN、Scr及血尿酸是影响冠心病患者冠脉血管钙化的危险因素。随着年龄增长，OPG、OPN、Scr及血尿酸水平升高，冠心病患者发生冠脉血管钙化的风险也相应增加。
Analysis of influencing factors for coronary artery calcification in patients with coronary heart disease
Objective To analyze the influencing factors of coronary artery calcification in patients with coronary heart disease,in order to provide references for clinical diagnosis and treatment of diseases.Methods The clinical data of 86 patients with coronary heart disease admitted in our hospital from May 2021 to May 2023 were retrospectively analyzed,including age,gender,body mass index(BMI),course of disease,combined diseases,blood lipid indexes[total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)],osteoprotegerin(OPG),osteopontin(OPN),serum creatinine(Scr),serum uric acid and blood pressure[systolic blood pressure(SBP),diastolic blood pressure(DBP)].The coronary artery calcification in patients with coronary heart disease were analyzed,and the influencing factors of coronary artery calcification in patients with coronary heart disease by multivariate Logistic regression analysis were analyzed.Results Among the 86 patients with coronary heart disease,69 patients(80.23%)had no coronary artery calcification and were included as non-occurrence group;there were 17 patients(19.77%)with coronary artery calcification,which was included as occurrence group.There were no significant differences in gender composition ratio,BMI,course of disease,composition ratio of combined diseases,blood lipid indexes and blood pressure between the two groups(P>0.05);the age,OPG,OPN,Scr and serum uric acid levels in the occurrence group were higher than those in the non-occurrence group,and the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that age,OPG,OPN,Scr and serum uric acid were independent risk factors for coronary artery calcification in patients with coronary heart disease(P<0.05).Conclusion Age,OPG,OPN,Scr and serum uric acid are risk factors for coronary artery calcification in patients with coronary heart disease.With the increase of age,OPG,OPN,Scr and serum uric acid levels,the risk of coronary artery calcification in patients with coronary heart disease increases accordingly.

coronary heart diseasecoronary artery calcificationosteoprotegerinosteopontinserum creatinineserum uric acid

王连友、李茂巍、程艳娜、尚冬升、于林君

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中国人民解放军联勤保障部队第九八八医院心内科,河南 郑州,450042

冠心病 冠脉血管钙化 骨保护素 骨桥蛋白 血肌酐 血尿酸

2021年度河南省医学科技攻关计划联合共建项目

LHGJ20210822

2024

10.19347/j.cnki.2096-1413.202429005

临床医学研究与实践

临床医学研究与实践

ISSN：
年,卷(期)：2024.9(29)