Effects of edaravone injection combined with alteplase intravenous thrombolysis on the levels of oxidized low-density lipoprotein and ischemia modified albumin in patients with acute ischemic stroke
Objective To analyze the clinical effect of edaravone injection combined with alteplase intravenous thrombolysis in the treatment of patients with acute ischemic stroke.Methods A total of 76 patients with acute ischemic stroke admitted in the hospital from March 2021 to February 2023 were selected as the research objects.According to the random number table method,the patients were divided into control group(38 cases,alteplase intravenous thrombolytic therapy)and study group(38 cases,edaravone injection combined with alteplase intravenous thrombolytic therapy).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the study group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of oxidized low-density lipoprotein(Ox-LDL),ischemia modified albumin(IMA),lipoprotein-associated phospholipase A2(Lp-PLA2),erythropoietin(EPO)and clusterin(CLU)in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the N-acetylaspartic acid/creatine(NAA/Cr)in the study group was higher than that in the control group,the choline-containing compounds/creatine(Cho/Cr)was lower than that in the control group,and the anisotropic scores of corpus callosum and inferior fronto-occipital fasciculus were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The edaravone injection combined with alteplase intravenous thrombolysis in the treatment of patients with acute ischemic stroke has a significant effect,it is helpful to regulate the body's serological indicators and promote the recovery of neurological function.
acute ischemic strokeedaravone injectionalteplaseintravenous thrombolysisneurological function
NETL
NSTL
万方数据
