Clinical effect of alternate use of high flow nasal cannula and non-invasive positive pressure ventilation in the treatment of elderly patients with severe pneumonia and respiratory failure
Objective To analyze the clinical effect of alternate use of high flow nasal cannula(HFNC)and non-invasive positive pressure ventilation(NIPPV)in the treatment of elderly patients with severe pneumonia(SP)and respiratory failure.Methods A total of 86 patients with SP and respiratory failure admitted from January 2020 to December 2022 were included in this study.The patients were divided into control group(43 cases,HFNC treatment)and study group(43 cases,HFNC and NIPPV alternate treatment)according to the difference of treatment plan.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the study group was significantly higher than that in the control group(P<0.05).After treatment,arterial partial pressure of oxygen(PaO2),arterial oxygen saturation(SaO2)and oxygenation index in the study group were higher than those in the control group,and arterial partial pressure of carbon dioxide(PaCO2)and sputum viscosity score were lower than those in the control group(P<0.05).After treatment,the levels of angiopoietin-2(Ang-2),progranulin(PGRN),high mobility group box 1 protein(HMGB-1),soluble triggering receptor expressed on myeloid cells-1(sTREM-1)and interleukin-6(IL-6)in the study group were lower than those in the control group(P<0.05).After treatment,the levels of aspartate aminotransferase(AST),lactic dehydrogenase(LDH),creatine kinase(CK)and creatine kinase isoenzymes(CK-MB)in the study group were significantly lower than those in the control group(P<0.05).Conclusion The alternate use of HFNC and NIPPV in the treatment of elderly patients with SP and respiratory failure has a significant effect,it can improve the blood gas indexes and sputum viscosity of patients,reduce the inflammatory response of the body,and relieve myocardial injury,which is worth promoting.
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