Effect of early internal carotid artery stenting in the treatment of carotid atherosclerotic cerebral infarction and its influences on coagulation function and cerebral hemodynamics
Objective To investigate the early internal carotid artery stenting in the treatment of carotid atherosclerotic cerebral infarction and its influences on coagulation function and cerebral hemodynamics.Methods A total of 200 patients with carotid atherosclerotic cerebral infarction admitted from January 2020 to January 2023 were selected as the research objects,and the patients were divided into control group and observation group by random number table method,with 100 cases in each group.The control group was treated with conservative treatment for 2 weeks,and the internal carotid artery stenting was implanted after the cerebral infarction was stable;the observation group was treated with internal carotid artery stenting implantation after 3-5 d of conservative treatment.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the prothrombin time(PT)and activated partial thromboplastin time(APTT)in the observation group were longer than those in the control group,and the fibrinogen(FIB)level was lower than that in the control group(P<0.05).After treatment,the peak velocity(VP)and mean flow velocity(MFV)of the observation group were higher than those of the control group,and the resistance index(RI)was lower than that of the control group(P<0.05).After treatment,the levels of high sensitivity C-reactive protein(hs-CRP),vascular endothelial growth factor(VEGF)and matrix metalloproteinase-9(MMP-9)in the observation group were lower than those in the control group(P<0.05).Conclusion Early internal carotid artery stenting can enhance the therapeutic effect of carotid atherosclerotic cerebral infarction,improve coagulation function and cerebral hemodynamics,and reduce inflammatory response.
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