Objective The immune infiltration related genes of esophageal squamous cell carcinoma(ESCC)were screened by bioinformatics methods.Methods The gene expression omnibus(GEO)was used to obtain ESCC-related data sets,the different expression immune-related genes(DEIRGs)between differential expression genes(DEGs)and immune-related genes(IRGs)were screened out,and DEIRGs were subjected to enrichment analysis and protein-protein interaction(PPI)network diagram was drawn.CIBERSORT and ESTIMATE methods were used to analyze the infiltration of immune cells in ESCC.Results A total of 53 DEIRGs were screened.CXCL8 ranked first in the PPI network.The results of ESTIMATE analysis showed that the matrix and immune scores in the the ESCC group were higher;and the results of CIBERSORT analysis showed that the infiltration level of CD8 T cells was lower in the ESCC group.Spearman correlation analysis results showed that CXCL8 gene was negatively correlated with CD8 T cells.Conclusion CXCL8 is a key gene related to immune infiltration,which is closely related to the occurrence and development of ESCC.
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