Clinical effect of live combined Bifidobacterium,Lactobacillus and Enterococcus capsules and lactulose combined with piperacillin/tazobactam in the treatment of liver cirrhosis complicated with spontaneous bacterial peritonitis
Objective To investigate the effect of live combined Bifidobacterium,Lactobacillus and Enterococcus capsules and lactulose combined with piperacillin/tazobactam in the treatment of liver cirrhosis complicated with spontaneous bacterial peritonitis(SBP).Methods A total of 88 patients with liver cirrhosis complicated with SBP admitted from March 2021 to April 2023 were selected and randomly divided into control group(44 cases,treated with piperacillin/tazobactam)and observation group(44 cases,treated with live combined Bifidobacterium,Lactobacillus and Enterococcus capsules and lactulose combined with piperacillin/tazobactam).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P＜0.05).The recovery time of body temperature,disappearance time of abdominal tenderness,normal time of routine examination of ascites and disappearance time of ascites in the observation group were shorter than those in the control group(P＜0.05).After 1 week of treatment,the levels of tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)in the observation group were lower than those in the control group,and the level of interleukin-10(IL-10)was higher than that in the control group(P＜0.05).After 1 week of treatment,the CD3+,CD4+,CD4+/CD8+and natural killer(NK)cells in the observation group were higher than those in the control group(P＜0.05).After 1 week of treatment,the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),γ-glutamyl transferase(GGT)and total bilirubin(TBIL)in the observation group were significantly lower than those in the control group(P＜0.05).Conclusion Live combined Bifidobacterium,Lactobacillus and Enterococcus capsules and lactulose combined with piperacillin/tazobactam can improve the clinical symptoms of patients with liver cirrhosis and SBP,and reduce the bodys'inflammatory response.
liver cirrhosisspontaneous bacterial peritonitispiperacillin/tazobactamlive combined Bifidobacterium,Lactobacillus and Enterococcus capsulelactulose
NETL
NSTL
万方数据
