Effects of different adjuvant chemotherapy regimens on blood lipid and body mass of patients with breast cancer after surgery
Objective To discuss the effects of different adjuvant chemotherapy regimens on blood lipid and body mass of patients with breast cancer after surgery.Methods A total of 121 patients with postoperative adjuvant chemotherapy for breast cancer in our hospital from July 2021 to December 2023 were selected as the research objects.According to the chemotherapy regimen,the patients were divided into epirubicin+cyclophosphamide followed by paclitaxel(EC-wP)group(n=58),taxotere+epirubicin+cyclophosphamide(TEC)group(n=16),epirubicin+cyclophosphamide(EC)group(n=37),taxotere+cyclophosphamide(TC)group(n=10).The blood lipids[triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)]levels and body mass index(BMI)before the first and last chemotherapy were compared among the four groups.Results There were no significant differences in TG,TC,LDL-C levels and BMI between before the first and last chemotherapy among all patients(P＞0.05);the HDL-C level of all patients before the last chemotherapy was lower than that before the first chemotherapy(P＜0.05).In the EC-wP group,the TG level before the last chemotherapy was higher than that before the first chemotherapy,and the HDL-C level was lower than that before the first chemotherapy(P＜0.05);there were no significant differences in TC,LDL-C levels and BMI between before the first and last chemotherapy in the EC-wP group(P＞0.05);the level of HDL-C in the TEC group,EC group and TC group before the last chemotherapy was lower than that before the first chemotherapy(P＜0.05);there were no significant differences in TG,TC,LDL-C levels and BMI between before the first and last chemotherapy in the TEC group,EC group and TC group(P＞0.05).Conclusion Adjuvant chemotherapy may has adverse effect on blood lipid level in patients with breast cancer after surgery,and may not has adverse effect on body mass.Among them,EC-wP regimen has a greater adverse effect on blood lipid,suggesting that patients need to strengthen blood lipid monitoring during chemotherapy.
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