Effects of dapagliflozin on cardiac function and atrial high rate episode in patients with high-grade atrioventricular block after pacemaker implantation
Objective To explore the effect of dapagliflozin on cardiac function and atrial high rate episode(AHRE)in patients with high-grade atrioventricular block after pacemaker implantation.Methods A total of 80 patients with high-grade atrioventricular block after pacemaker implantation admitted in the cardiology department of our hospital from June 2022 to June 2023 were selected as the research objects.The patients were divided into control group and study group by random number table method,with 40 cases in each group.The control group was treated with sacubitril valsartan on the basis of conventional anti heart failure treatment,and the study group was treated with dapagliflozin on the basis of the control group.The therapeutic effects of the two groups were compared.Results Before and after treatment,there was statistically significant difference in New York Heart Association(NYHA)classification of the study group(P＜0.05);before and after treatment,there was statistically significant difference in NYHA classification of the control group(P＜0.05).After treatment,the left ventricular ejection fraction(LVEF)and fractional shortening(FS)in the two groups were significantly higher than those before treatment,and those in the study group were higher than the control group(P＜0.05).After treatment,the 6 min walking test distance of the two groups was longer than that before treatment,the brain natriuretic peptide(BNP)level was lower than that before treatment,and those in the study group were better than the control group(P＜0.05).At discharge and 6 months of follow-up,the frequency of atrial fibrillation in the study group was lower than that in the control group,and the duration of atrial fibrillation was shorter than that in the control group(P＜0.05);at 6 months of follow-up,the frequency of atrial fibrillation in the study group was lower than that at discharge,and the duration of atrial fibrillation was shorter than that at discharge(P＜0.05).Conclusion Dapagliflozin can effectively improve the cardiac function of patients with high-grade atrioventricular block after pacemaker implantation,and also effectively reduce the risk of AHRE.
dapagliflozinatrioventricular blockpacemaker implantationatrial high rate episode
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