Efficacy and safety of pituitrin combined with somatostatin in the treatment of upper gastrointestinal bleeding caused by cirrhosis
Objective To study the efficacy and safety of pituitrin combined with somatostatin in the treatment of upper gastrointestinal bleeding caused by cirrhosis.Methods A total of 100 patients with upper gastrointestinal bleeding caused by cirrhosis admitted in our hospital from January 2021 to January 2022 were selected as the research objects.The patients were divided into control group and observation group by random number table method,with 50 cases in each group.The control group was treated with somatostatin,and the observation group was treated with pituitrin combined with somatostatin.The clinical efficacy,laboratory indexes and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 96.00％,which was higher than 84.00％in the control group,and the difference was statistically significant(P＜0.05).After treatment,the levels of fibrinogen(Fib)and D-dimer(D-D)in the observation group were higher than those in the control group,the prothrombin time(PT)and activated partial thromboplastin time(APTT)were shorter than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,the whole blood high shear viscosity,whole blood low shear viscosity and plasma viscosity in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,the levels of endothelin-1(ET-1)and nitric oxide(NO)in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Pituitrin combined with somatostatin is effective in the treatment of upper gastrointestinal bleeding caused by cirrhosis.It can not only improve coagulation function and hemorheology,but also reduce the level of vasoactive factors,and has high safety.
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