Application effect of laparoscopic assisted total gastrectomy in patients with locally advanced gastric cancer at different ages
Objective To analyze the application effect of laparoscopic assisted total gastrectomy in patients with locally advanced gastric cancer(LAGC)at different ages.Methods A total of 80 patients with LAGC admitted from April 2017 to April 2023 were enrolled in this study.The patients were divided into group A(≤55 years old,n=11),group B(56-70 years old,n=28)and group C(＞70 years old,n=41).All three groups were treated with laparoscopic assisted total gastrectomy.The surgical effects of the three groups were compared.Results There were no significant differences in operation time,intraoperative blood loss,number of lymph node dissection,postoperative exhaust time,time to return to normal diet and total hospitalization time among the three groups(P＞0.05).There was no significant difference in the total incidence of postoperative complications among the three groups(P＞0.05).Before and after operation,the levels of C-reactive protein(CRP),norepinephrine(NE),prostaglandin E2(PGE2),myeloperoxidase(MPO),carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199)and carbohydrate antigen 724(CA724)were compared among the three groups,the differences were not statistically significant(P＞0.05);after operation,the levels of CRP,NE,PGE2 and MPO in the three groups were higher than those before operation,and the levels of CEA,CA199 and CA724 were lower than those before operation,the differences were statistically significant(P＜0.05).Conclusion Laparoscopic assisted total gastrectomy can achieve better surgical results in LAGC patients of different ages,and does not increase stress response and serious complications,which is worthy of clinical application and promotion.
locally advanced gastric cancerlaparoscopytotal gastrectomydifferent agenumber of lymph node dissection
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