Value of PCT,CRP,IL-6 and IL-10 in the identification of bacterial types and prognosis evaluation of blood stream infection
Objective To analyze the value of procalcitonin(PCT),C-reactive protein(CRP),interleukin-6(IL-6)and interleukin-10(IL-10)in the identification of bacterial types and prognosis evaluation of blood stream infection(BSI).Methods A total of 80 patients with BSI diagnosed from January 2021 to December 2022 were selected as observation group,and 40 healthy people who underwent physical examination during the same period were selected as control group.Blood samples of the subjects were collected to detect white blood cell count(WBC),PCT,CRP,IL-6 and IL-10 levels.The levels of WBC,PCT,CRP,IL-6 and IL-10 of the two groups of subjects,patients with Gram-positive bacterial infection and Gram-negative bacterial infection,and patients with different prognosis outcomes at admission and 7 d after admission were compared.Results The levels of WBC,PCT,CRP and IL-6 in the observation group were higher than those in the control group,and the level of IL-10 was lower than that in the control group,and the differences were statistically significant(P＜0.05).The WBC,PCT and CRP of patients with Gram-positive bacterial infection were lower than those of patients with Gram-negative bacterial infection,and the differences were statistically significant(P＜0.05).There was no significant difference in WBC at admission between patients with different prognosis(P＞0.05);with the deterioration of prognosis,the levels of PCT,CRP and IL-6 in the observation group showed an increasing trend at admission and 7 d after admission,and the level of IL-10 showed a decreasing trend except for the deterioration of prognosis;the levels of WBC,PCT,CRP and IL-6 at 7 d after admission in recovered and improved patients were lower than those at admission,and the level of IL-10 was higher than that at admission,and the differences were statistically significant(P＜0.05).Conclusion WBC can well determine whether there is infection in patients.WBC and PCT can identify the type of infectious bacteria.CRP,IL-6,IL-10 and other inflammatory markers can predict the prognosis of patients,which is worthy of clinical promotion and application.
blood stream infectionbacteria typeprognosisinterleukin-6interleukin-10procalcitoninC-reactive protein
NETL
NSTL
万方数据
