Application effect of Mashao Pingchuan decoction in bronchial asthma(cold asthma syndrome)and its influence on airway remodeling
Objective To explore the application effect of Mashao Pingchuan decoction in bronchial asthma(cold asthma syndrome)and its influence on airway remodeling.Methods A total of 103 patients with bronchial asthma(cold asthma syndrome)admitted from January 2018 to May 2022 were selected as the research objects and divided into control group(n=50)and observation group(n=53)according to the random number table method.The control group was treated with conventional western medicine regimen,and the observation group was treated with Mashao Pingchuan decoction on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P＜0.05).After treatment,the levels of transforming growth factor-β1(TGF-β1),osteopontin(OPN)and matrix metalloproteinase-9(MMP-9)in the observation group were significantly lower than those in the control group(P＜0.05).After treatment,the helper T cell 1(Th1)and helper T cell 1(Th1)/helper T cell 2(Th1/Th2)in the observation group were higher than those in the control group,and the Th2 was lower than that in the control group(P＜0.05).Conclusion The Mashao Pingchuan decoction in the treatment of bronchial asthma(cold asthma syndrome)has a significant effect.It can effectively inhibit airway remodeling and regulate Th1/Th2 balance,which is worthy of clinical application and promotion.
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