Correlation between thyroid autoantibodies and clinical features and prognosis of patients with papillary thyroid carcinoma
Objective To analyze the correlation between thyroid autoantibodies and clinical features and prognosis of patients with papillary thyroid carcinoma(PTC).Methods A total of 786 PTC patients admitted in our hospital from January 2019 to December 2020 were enrolled in PTC group,and 352 benign nodular thyroid cyst patients admitted during the same period were enrolled in benign nodular thyroid cyst group.The positive rates of thyroid peroxidase antibody(TPOAb)and thyroid globulin antibody(TGAb)were compared between the two groups;the clinical features and survival of patients with different levels of TPOAb and TGAb in the PTC group were compared.Results The positive rates of TPOAb and TGAb in the PTC group were higher than those in the benign nodular thyroid cyst group(P<0.05).The tumor diameter and the proportion of lymph node metastasis,extraglandular dissemination and vascular invasion in the TPOAb positive patients were significantly higher than those in the TPOAb negative patients of the PTC group(P<0.05).The tumor diameter and the proportion of male,capsule invasion and vascular invasion in the TGAb positive patients were significantly higher than those in the TGAb negative patients of the PTC group(P<0.05).The proportion of metastasis or recurrence after PTC treatment in the TPOAb and TGAb positive patients were significantly higher than those in the TPOAb and TGAb negative patients(P<0.05).The average disease-free survival time of the TPOAb and TGAb positive patients were shorter than those of the TPOAb and TGAb negative patients(P<0.05).Conclusion TPOAb and TGAb can be used as effective indicators to evaluate the changes of PTC patients and predict the prognosis.
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