Effect of sacubactril valsartan sodium tablets combined with metoprolol succinate sustained-release tablets in the treatment of chronic congestive heart failure
Objective To analyze the efficacy and safety of sacubitril valsartan sodium tablets combined with metoprolol succinate sustained-release tablets in the treatment of chronic congestive heart failure(CCHF).Methods A total of 80 CCHF patients admitted in the No.1 internal medicine department of Zichang People's Hospital from January 2021 to December 2022 were selected as the research objects.According to the different treatment regimens,the patients were divided into single drug group(n=40,metoprolol succinate sustained-release tablets treatment)and combined group(n=40,sacubitril valsartan sodium tablets combined with metoprolol succinate sustained-release tablets treatment).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the combined group was significantly higher than that in the single drug group(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)in the combined group was significantly higher than that in the single drug group,left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)and diastolic interventricular septal thickness(IVST)were significantly smaller than those in the single drug group(P<0.05).After treatment,the levels of N-terminal pro-B-type natriuretic peptide(NT-proBNP),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6)and intercellular adhesion molecule-1(ICAM-1)in the combined group were significantly lower than those in the single drug group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Sacubitril valsartan sodium tablets combined with metoprolol succinate sustained-release tablets has an ideal effect in treatment of CCHF,it can effectively improve cardiac function and biochemical indexes of patients,and does not increase adverse drug reactions,with high safety.
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