临床医学研究与实践2024，Vol.9Issue(34) ：135-138.DOI:10.19347/j.cnki.2096-1413.202434034

芪术胶囊联合恩格列净治疗早期糖尿病肾病患者的临床效果

Clinical effect of Qizhu capsules combined with empagliflozin in the treatment of patients with early diabetes kidney disease

杨敏 韦阳
临床医学研究与实践2024，Vol.9Issue(34) ：135-138.DOI:10.19347/j.cnki.2096-1413.202434034
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芪术胶囊联合恩格列净治疗早期糖尿病肾病患者的临床效果

Clinical effect of Qizhu capsules combined with empagliflozin in the treatment of patients with early diabetes kidney disease

杨敏 1韦阳1
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作者信息

  • 1. 铜川市人民医院,陕西 铜川,727000
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摘要

目的 探讨芪术胶囊联合恩格列净治疗早期糖尿病肾病患者的临床效果.方法 选取 2020 年 3 月至2022年6月我院收治的94例早期糖尿病肾病患者为研究对象,按照治疗方式不同将其分为对照组(47例,恩格列净治疗)和观察组(47 例,芪术胶囊联合恩格列净治疗).比较两组的治疗效果.结果 观察组的治疗总有效率为 95.74%,高于对照组的 78.72%(P<0.05).治疗后,观察组的空腹血糖(FBG)、餐后 2h血糖(2h PBG)及糖化血红蛋白(HbA1c)水平低于对照组(P<0.05).治疗后,观察组的血肌酐(SCr)、尿素氮(BUN)、24h尿蛋白定量、胱抑素C(CysC)、C1q及转铁蛋白(TRF)水平低于对照组(P<0.05).治疗后,观察组的超氧化物歧化酶(SOD)水平高于对照组,丙二醛(MDA)水平低于对照组(P<0.05).结论 芪术胶囊联合恩格列净可降低早期糖尿病肾病患者的血糖水平,提高肾功能,改善氧化应激指标.

Abstract

Objective To explore the clinical effect of Qizhu capsules combined with empagliflozin in the treatment of patients with early diabetes kidney disease.Methods A total of 94 patients with early diabetes kidney disease admitted in our hospital from March 2020 to June 2022 were selected as the research objects.According to different treatment methods,the patients were divided into control group(47 cases,treated with empagliflozin)and observation group(47 cases,treated with Qizhu capsules combined with empagliflozin).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was 95.74%,which was higher than 78.72%in the control group(P<0.05).After treatment,the levels of fasting blood glucose(FBG),2 h postprandial blood glucose(2 h PBG)and glycosylated hemoglobin(HbA1c)in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of serum creatinine(SCr),blood urea nitrogen(BUN),24 h urine protein quantification,cystatin C(CysC),C1q and transferrin(TRF)in the observation group were lower than those in the control group(P<0.05).After treatment,the level of superoxide dismutase(SOD)in the observation group was higher than that in the control group,and the level of malonaldehyde(MDA)was lower than that in the control group(P<0.05).Conclusion Qizhu capsules combined with empagliflozin can reduce the blood glucose level of patients with early diabetes kidney disease,elevate renal function,and improve oxidative stress indicators.

关键词

芪术胶囊/恩格列净/早期糖尿病肾病

Key words

Qizhu capsule/empagliflozin/early diabetes kidney disease

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出版年

2024
临床医学研究与实践

临床医学研究与实践

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