Clinical application of Lp-PLA2 and sLOX-1 in acute cerebral infarction
Objective To explore the clinical application of lipoprotein-associated phospholipase A2(Lp-PLA2)and soluble lection-like oxidized low-density lipoprotein receptor-1(sLOX-1)in acute cerebral infarction(ACI).Methods A total of 181 patients with ACI who were admitted to our hospital from July 2021 to January 2023 were selected as ACI group,and 154 healthy people who received general clinical examination during the same period were selected as control group.The levels of Lp-PLA2 and sLOX-1 of the two groups were compared.The National Institutes of Health Stroke Scale(NIHSS)was used to evaluate the degree of neurological deficits in the ACI group after admission,and the relationship between Lp-PLA2 and sLOX-1 and NIHSS was analyzed.The sensitivity and specificity of Lp-PLA2 and sLOX-1 alone and in combination in the diagnosis of ACI were analyzed by ROC curve.Results The levels of Lp-PLA2 and sLOX-1 in the ACI group were higher than those in the control group,and the differences were statistically significant(P＜0.001).The AUC of Lp-PLA2,sLOX-1 and Lp-PLA2 combined with sLOX-1 in the diagnosis of ACI were 0.704,0.774 and 0.787,respectively.The levels of Lp-PLA2 and sLOX-1 were positively correlated with NIHSS score(P＜0.05).Conclusion The levels of Lp-PLA2 and sLOX-1 are significantly correlated with the occurrence of ACI and the degree of neurological impairment in ACI patients,and have certain diagnostic value for ACI.
万方数据
维普
