Effects of different proportions of suspended red blood cells and fresh frozen plasma on coagulation and fibrinolysis function and prognosis in patients with acute trauma undergoing massive blood transfusion
Objective To explore the effects of different proportions of suspended red blood cells(SRBC)and fresh frozen plasma(FFP)on coagulation and fibrinolysis function and prognosis in patients with acute trauma undergoing massive blood transfusion.Methods A total of 100 patients with acute trauma undergoing massive blood transfusion admitted from March 2021 to March 2023 in our department were selected as the research objects.According to the input proportion of SRBC and FFP,the patients were divided into group A and group B,with 50 cases in each group.The SRBC∶FFP of the group A was 1∶1,and the SRBC∶FFP of the group B was 2∶1.The therapeutic effects of the two groups were compared.Results After blood transfusion,prothrombin time(PT)and activated partial thromboplastin time(APTT)in the group A were shorter than those in the group B,and fibrinogen(FIB)level was higher than that in the group B(P＜0.05).After blood transfusion,the levels of protein C(PC)and D-dimer(D-D)in the group A were higher than those in the group B(P＜0.05);after blood transfusion,there was no significant difference in the fibrinogen degradation products(FDP)level between the two groups(P＞0.05).There was no significant difference in the total incidence of adverse transfusion reactions between the two groups(P＞0.05).The Sequential Organ Failure Assessment(SOFA)score of the group A was lower than that of the group B(P＜0.05);there was no significant difference in hospitalization time between the two groups(P＞0.05).Conclusion SRBC∶FFP infusion at a ratio of 1∶1 can better maintain the coagulation and fibrinolysis function of patients with acute trauma undergoing massive blood transfusion,improve the prognosis,and has high safety,which is worthy of promotion.
acute traumamassive blood transfusionsuspended red blood cellsfresh frozen plasmacoagulation and fibrinolysis functionprognosis
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维普
