Effects of thrombelastogram parameters guided blood transfusion therapy on platelet activation function and fibrinolytic function in high-risk pregnant women with postpartum hemorrhage
Objective To explore the effects of thrombelastogram parameters guided blood transfusion therapy on platelet activation function and fibrinolytic function in high-risk pregnant women with postpartum hemorrhage.Methods A total of 80 high-risk pregnant women with postpartum hemorrhage admitted in our hospital from January 2021 to January 2023 were selected as the research objects.According to different blood transfusion guidance methods,the pregnant women were divided into control group(40 cases,guided by routine blood transfusion treatment)and observation group(40 cases,guided by thrombelastogram parameters).The therapeutic effects of the two groups were compared.Results After treatment,the reaction time(R)and kinetics time(K)in the observation group were shorter than those in the control group,and the a angle and maximum amplitude(MA)were greater than those in the control group,and the differences were statistically significant(P＜0.05).After treatment a-granule membrane protein-140(GMP-140)level and platelet maximum aggregation rate(MAR)in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,the levels of fibrinogen degradation products(FDP)and D-dimers(D-D)in the observation group were higher than those in the control group,and the level of protein C(PC)was lower than that in the control group,and the differences were statistically significant(P＜0.05).Conclusion Thrombelastogram parameters guided blood transfusion therapy can more effectively improve platelet activation function and fibrinolytic function in high-risk pregnant women with postpartum hemorrhage,which is worthy of promotion.
thrombelastography parameterblood transfusionhigh-risk pregnancypostpartum hemorrhageplatelet activation functionfibrinolytic function
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维普
