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脑小血管病内皮功能障碍的生物标志物研究进展

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随着世界人口老龄化的加剧,脑小血管病(CSVD)发病率逐渐升高,对人们的生活和健康造成了极大威胁。该病隐匿,临床症状各异,易被忽略,同时缺乏有效的治疗手段。相关研究证明,内皮功能障碍参与了CSVD的发生与发展过程。本文旨在对CSVD的发病机制——内皮功能障碍的生物标志物进行综述,进一步探究CSVD的危险因素及其作用机制,为临床诊疗提供参考和新思路。
Research progress on biomarkers of endothelial dysfunction in cerebral small vessel disease
With the aging of the world's population,the incidence of cerebral small vessel disease(CSVD)has gradually increased,posing a great threat to people's lives and health.The disease is hidden,has different clinical symptoms,and is easily ignored.At the same time,there is a lack of effective treatment.Relevant studies have proven that endothelial dysfunction is involved in the occurrence and development of CSVD.This article aims to review the pathogenesis of CSVD-biomarkers of endothelial dysfunction,further explore the risk factors of CSVD and its mechanism of action,and provide reference and new ideas for clinical diagnosis and treatment.

cerebral small vessel diseaseendothelial dysfunctionbiomarker

刘聪杰、肖艾妮、王翔宇

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三峡大学第三临床医学院/国药葛洲坝中心医院神经内科,湖北宜昌,443000

脑小血管病 内皮功能障碍 生物标志物

2024

临床医学研究与实践

临床医学研究与实践

ISSN:
年,卷(期):2024.9(35)