Application effect of different intensity rivaroxaban anticoagulation therapy in elderly patients with stable coronary heart disease complicated with non-valvular atrial fibrillation
Objective To analyze the application effect of different intensity rivaroxaban anticoagulation therapy in elderly patients with stable coronary heart disease complicated with non-valvular atrial fibrillation.Methods A total of 120 elderly patients with stable coronary heart disease complicated with non-valvular atrial fibrillation admitted from January 2021 to January 2022 were selected as the study objects.According to the different doses of administration,the patients were divided into low-dose group(n=40,10 mg rivaroxaban),middle-dose group(n=40,15 mg rivaroxaban)and high-dose group(n=40,20 mg rivaroxaban).The coagulation function,major adverse cardiac events(MACE),bleeding and adverse reactions were compared among the three groups.Results After treatment,the prothrombin time(PT),thrombin time(TT)and activated partial thromboplastin time(APTT)of the three groups were prolonged,and the international normalized ratio(INR)was increased(P＜0.05);after treatment,there were no significant differences in PT,TT,APTT and INR among the three groups(P＞0.05).There was no significant difference in the total incidence of MACE among the three groups(P＞0.05).There was a statistically significant difference in the total incidence of bleeding among the three groups(P＜0.05).There was no significant difference in the total incidence of adverse reactions among the three groups(P＞0.05).Conclusion Different intensity rivaroxaban anticoagulant therapy in elderly patients with stable coronary heart disease complicated with non-valvular atrial fibrillation has a good application effect,and the anticoagulant effect of high-dose rivaroxaban is more obvious,but it is easy to lead to bleeding tendency,so it is more recommended to use low-dose rivaroxaban.
万方数据
维普
