Effect of vitamin E combined with calcium,low-dose aspirin and nifedipine in the treatment of gestational hypertension and its influences on PLGF and sFlt-1 levels
Objective To investigate the effect of vitamin E combined with calcium,low-dose aspirin and nifedipine in the treatment of gestational hypertension and its influences on the levels of placental growth factor(PLGF)and soluble fms-like tyrosine kinase receptor-1(sFlt-1).Methods A total of 100 patients with gestational hypertension admitted from January 2021 to January 2023 were selected and divided into control group and observation group by random number table method,with 50 cases in each group.The control group was treated with low-dose aspirin and nifedipine,and the observation group was treated with vitamin E and calcium gluconate on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the systolic blood pressure(SBP),diastolic blood pressure(DBP)and mean artery pressure(MAP)in the observation group were lower than those in the control group(P＜0.05).After treatment,the levels of soluble vascular cell adhesion molecule-1(sVCAM-1),receptor for advanced glycosylation end products(RAGE)and endothelin-1(ET-1)in the observation group were lower than those in the control group(P＜0.05).The total incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group(P＜0.05).After treatment,the PLGF level in the observation group was higher than that in the control group,and the sFlt-1 level was lower than that in the control group(P＜0.05).Conclusion Vitamin E combined with calcium,low-dose aspirin and nifedipine in the treatment of patients with gestational hypertension can promote the reduction of blood pressure level,improve vascular endothelial function,reduce adverse pregnancy outcomes.
万方数据
维普
