目的 分析低分子肝素联合小剂量阿司匹林对妊娠期高血压疾病患者不良妊娠结局发生情况的影响。方法 选取90例妊娠期高血压疾病患者为研究对象，随机将其分为常规组(45例，常规降压治疗+小剂量阿司匹林)和观察组(45例，常规降压治疗+小剂量阿司匹林+低分子肝素)。比较两组的治疗效果。结果 观察组的治疗总有效率显著高于常规组(P＜0。05)。观察组的母婴不良妊娠结局总发生率显著低于常规组(P＜0。05)。治疗后，观察组的搏动指数(PI)、阻力指数(RI)、收缩期峰值血流速度与舒张末期血流速度比值(S/D)均显著低于常规组(P＜0。05)。治疗后，观察组的24 h尿蛋白定量(24 h UPQ)及谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)、总胆汁酸(TBA)水平均显著低于常规组(P＜0。05)。两组治疗期间的不良反应总发生率无显著差异(P＞0。05)。结论 低分子肝素联合小剂量阿司匹林治疗妊娠期高血压疾病效果显著，且安全性较高。
Effect of low molecular weight heparin combined with low-dose aspirin on adverse pregnancy outcomes in patients with hypertensive disorder complicating pregnancy
Objective To analyze the effect of low molecular weight heparin combined with low-dose aspirin on adverse pregnancy outcomes in patients with hypertensive disorder complicating pregnancy.Methods A total of 90 patients with hypertensive disorder complicating pregnancy were selected as the research objects and randomly divided into conventional group(45 cases,routine antihypertensive therapy+low-dose aspirin)and observation group(45 cases,routine antihypertensive therapy+low-dose aspirin+low molecular weight heparin).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the conventional group(P＜0.05).The total incidence of maternal and infant adverse pregnancy outcomes in the observation group was significantly lower than that in the conventional group(P＜0.05).After treatment,pulsatility index(PI),resistance index(Rl)and the ratio of peak systolic blood flow velocity to end diastolic blood flow velocity(S/D)in the observation group were significantly lower than those in the conventional group(P＜0.05).After treatment,the levels of 24 h urine protein quantification(24 h UPQ),alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL)and total bile acids(TBA)in the observation group were significantly lower than those in the conventional group(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups during treatment(P＞0.05).Conclusion Low molecular weight heparin combined with low-dose aspirin in the treatment of hypertensive disorder complicating pregnancy has a significant effect,and high safety.
万方数据
维普
