Expression of MCP-1,SFRP-4 and SAA in diabetic kidney disease and their correlation with glucose and lipid metabolism
Objective To analyze the expression of monocyte chemoattractant protein-1(MCP-1),recombinant secreted frizzled related protein-4(SFRP-4)and serum amyloid A(SAA)in diabetic kidney disease and their correlation with glucose and lipid metabolism.Methods A total of 80 patients with diabetic kidney disease admitted in our hospital from January 2021 to January 2023 were selected as the study group,and 80 patients with diabetes were selected as the control group.The levels of MCP-1,SFRP-4,SAA and glucose and lipid metabolism in the two groups were detected,and the correlation between them was analyzed.Results The levels of MCP-1,SFRP-4 and SAA in the study group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The levels of fasting plasma glucose(FPG),total cholesterol(TC)and triglyceride(TG)in the study group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The levels of MCP-1,SFRP-4,SAA,FPG,TC and TG in patients with stage Ⅰ in the study group were the lowest,those in stage Ⅱ and stage Ⅲincreased in turn,and those in stage Ⅳ were the highest.There were significant differences in the levels of MCP-1,SFRP-4 and SAA among patients with different stages in the study group(P＜0.05).There were statistically significant differences in FPG,TC and TG levels among patients with different stages in the study group(P＜0.05).Pearson correlation analysis showed that MCP-1,SFRP-4 and SAA were positively correlated with FPG,TC and TG(P＜0.05).Conclusion MCP-1,SFRP-4 and SAA are abnormally expression in the serum of patients with diabetic kidney disease,and their expressions are positively correlated with the glucose and lipid metabolism in patients.
monocyte chemoattractant protein-1serum amyloid Arecombinant secreted frizzled related protein-4diabetic kidney diseaseglucose and lipid metabolism
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