Correlation analysis between D-D,TBiL levels and degree of illness and coagulation function in newborns with hyperbilirubinemia
Objective To explore the correlation between D-dimer(D-D),total bilirubin(TBiL)levels and degree of illness and coagulation function in newborns with hyperbilirubinemia.Methods A total of 100 newborns with hyperbilirubinemia who were hospitalized in the neonatal department of our hospital from January 2020 to December 2022 were selected as observation group,and 100 healthy newborns in our hospital during the same period were selected as control group.The serum D-D,TBiL levels and coagulation function indexes of the two groups were measured;the correlation between the levels of D-D and TBiL and degree of illness and coagulation function in children with hyperbilirubinemia were analyzed;the predictive value of D-D,TBiL and D-D combined with TBiL for neonatal hyperbilirubinemia was analyzed by receiver operating characteristic(ROC)curve.Results The levels of serum D-D and TBiL in the observation group were significantly higher than those in the control group(P＜0.05).The levels of serum D-D and TBiL in the severe group were significantly higher than those in the moderate group and the mild group,and the levels of serum D-D and TBiL in the moderate group were significantly higher than those in the mild group(P＜0.05);Spearman correlation analysis showed that serum D-D and TBiL levels were significantly positively correlated with the severity of hyperbilirubinemia in children(P＜0.01).The prothrombin time(PT),activated partial prothrombin time(APTT)and thrombin time(TT)of the observation group were significantly longer than those of the control group,and the fibrinogen(FIB)level was significantly lower than that of the control group(P＜0.05).The levels of D-D and TBiL were positively correlated with PT,APTT and TT in children with hyperbilirubinemia,and negatively correlated with FIB level(P＜0.01).The area under curve(AUC)of D-D,TBiL and D-D combined with TBiL in predicting neonatal hyperbilirubinemia were 0.635,0.743 and 0.819,respectively;the combined detection had the highest predictive value.Conclusion The levels of serum D-D and TBiL are related to the degree of illness and coagulation function of newborns with hyperbilirubinemia,which may be used as indicators to predict the occurrence and evaluation of neonatal hyperbilirubinemia,and provide reference for clinical diagnosis and treatment.
newbornhyperbilirubinemiaD-dimertotal bilirubindegree of illnesscoagulation functionprothrombin time
万方数据
维普
