Effect of Dingkundan combined with estradiol and dydrogesterone in the treatment of perimenopausal syndrome and its influence on neurotransmitter levels
Objective To investigate the effect of Dingkundan combined with estradiol and dydrogesterone in the treatment of perimenopausal syndrome and its influence on neurotransmitter levels.Methods A total of 100 patients with perimenopausal syndrome admitted from January 2020 to December 2022 were selected as the study objects and randomly divided into control group(50 cases)and observation group(50 cases).The control group was treated with estradiol and dydrogesterone,and the observation group was treated with Dingkundan on the basis of the control group.The clinical efficacy,neurotransmitter level and quality of life were compared between the two groups.Results The total effective rate of treatment in the observation group was 92.00％,which was higher than 76.00％in the control group(P＜0.05).After treatment,the levels of 5-hydroxytryptamine(5-HT),dopamine(DA),brain-derived neurotrophic factor(BDNF)and norepinephrine(NE)in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,the scores of each dimension of Menopause-Specific Quality of Life(MENQOL)in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Dingkundan combined with estradiol and dydrogesterone in the treatment of perimenopausal syndrome can not only elevate the clinical effect,but also regulate the level of neurotransmitters and improve the quality of life,which is worthy of promotion.
Dingkundanestradiol and dydrogesteroneperimenopausal syndromeneurotransmitter
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