首页|牙髓干细胞成牙向分化中的相关信号通路

牙髓干细胞成牙向分化中的相关信号通路

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牙髓干细胞(DPSCs)具有高度增殖、自我更新能力和多向分化潜能,其最显著的特征是分化为成牙本质细胞。再生医学与口腔医学的联合发展使得基于DPSCs定向分化的牙再生成为可能,目前针对该过程所涉及信号通路的研究以单个信号通路为主。本文就近年来有关DPSCs成牙向分化主要相关信号通路的研究进展作一综述,为深入研究DPSCs定向分化及牙再生提供理论基础。
Related signaling pathways in odontogenic differentiation of dental pulp stem cells
Dental pulp stem cells(DPSCs)have high proliferation,self-renewal ability and multidirectional differentiation potential,and the most significant feature is differentiation into odontoblasts.The joint development of regenerative medicine and stomatology has made it possible to regenerate teeth based on the directed differentiation of DPSCs,and the current research on the signaling pathways involved in this process is mainly based on individual signaling pathways.This article reviews the recent research progress on the main signaling pathways related to the odontogenic differentiation of DPSCs,and provides a theoretical basis for in-depth study of the directional differentiation and tooth regeneration of DPSCs.

signaling pathwaydental pulp stem cellodontogenic differentiationodontogenesis

鲁奕男、潘泓乐、陈伯玮、李睿敏

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宁夏医科大学口腔医学院,宁夏银川,750004

宁夏医科大学总医院口腔医院牙体牙髓病科,宁夏 银川,750004

信号通路 牙髓干细胞 成牙分化 牙齿发育

2024

临床医学研究与实践

临床医学研究与实践

ISSN:
年,卷(期):2024.9(36)