Frailty is a geriatric syndrome,which is closely related to various adverse clinical outcomes in older adults.Multimorbidity is a clinical problem which leads to the occurrence of the above adverse clinical events in older a-dults.Studies have shown that frailty and multimorbidity often coexist in older people,and there are interactions between them.This review summarizes the interactions between frailty and multimorbidity,aiming to provide clinicians with valua-ble information to better cope with the challenges of ageing.