Objective To systematically review biomarkers of nutritional status in hospitalized elderly patients,with the goal of exploring changes in nutritional-related indicators in elderly patients with comorbidities and analyzing their clinical significance.Methods A total of 224 elderly patients with comorbidities were selected from the Depart-ment of Geriatric at Anhui Provincial Hospital Affiliated of Anhui Medical University between January 2017 and June 2023.Using the Mini Nutrition Evaluation Questionnaire to classify the nutritional status of research subjects,analyze multiple biological indicators closely related to nutritional status assessment,and evaluate the influencing factors of nutri-tional status.Results(1)Significant statistical differences were observed in the anthropometric and biochemical indi-cators among the groups with good nutrition,potential malnutrition,and malnutrition(P<0.05).(2)A significant statis-tical difference was found in the anthropometric and biochemical indicators between patients with and without cancer(P<0.05).Conclusions(1)The nutritional status of elderly patients with comorbidities is influenced by multiple factors.This study revealed some independent influencing factors,including calf circumference,BMI,hemoglobin,and uric acid.(2)The elderly patients with cancer had significantly higher hospitalization days,CCI scores,and total costs.