Aortic aneurysm is a type of aortic disease characterized by irreversible permanent dilation of the a-orta.Epidemiologically genetic components and advanced ages are identified as critical risk factors for aortic aneurysm.By far,more than one thousand of genes have been associated with the disease.On the other hand,the incidence of aortic aneurysm is sharply increased with ages.However,whether aging shift the expression of these genes contributes to the de-velopment of aortic aneurysm remains largely unknown.Here we focus on searching for aortic aneurysm-associated genes that are linked to cellular senescence,discussing the possible mechanisms how aging increases the susceptibility of aortic aneurysm via changing these genes.This review provides a notion whether aortic aneurysm can be prevented by the slow-down of aging process.
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