Objective To explore the relationship between insulin resistance and cognitive dysfunction in the elderly in urban communities,and to provide new ideas for the early identification and prevention of cognitive dysfunction in the elderly.Methods From January 2019 to July 2022,a total of 495 elderly people aged 60 and above were includ-ed in a community in Hefei City.Basic data(including gender,age,educational level,height,weight,body mass index,waist-to-hip ratio,etc.),medical history,and biochemical indicators(including blood lipid,fasting blood glucose,fasting insulin,glycated hemoglobin,25 hydroxyvitamin D,etc.)were recorded.Cognitive function level was assessed by the Montreal Cognitive Assessment(MoCA).Subjects were divided into a cognitive impairment group(MC group)and a non-MC group(non-MC group)according to MoCA score.Factors affecting the occurrence of cognitive impairment were analyzed,and insulin resistance(IR)level was assessed according to the homeostasis model Insulin resistance index(HOMA-IR),and divided into 4 groups by HOMA-IR quartile method,Q1:HOMA-IR≤1.325 2,Q2:1.325 2＜HO-MA-IR≤1.995 8,Q3:1.995 8＜HOMA-IR ≤2.646 5,Q4:HOMA-IR＞2.646 5,the prevalence of cognitive impair-ment in the four groups was compared,and the relationship between insulin resistance and cognitive impairment was ana-lyzed by binary logistic regression.Results Compared with the n-MC group,the MC group was older and less educated(P＜0.05),but there was no significant difference in hypertension history,diabetes history,marital status,and working status between the two groups(P＞0.05).The levels of HbA1c,total cholesterol,and HOMA-IR in the MC group were higher,while the levels of vitamin D were lower,and the difference was statistically significant(P＜0.05).The increase in HOMA-IR value was positively correlated with the occurrence of cognitive dysfunction(P＜0.01).Conclusion In-sulin resistance is a risk factor for cognitive impairment in elderly people in urban communities.
维普
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