Relationship between adipokines,Chinese visceral adiposity index and blood glucose fluctuation,diabetic micro-vascular complications in patients with obesity and T2DM
Objective To explore the relationship between adipokine,Chinese visceral adiposity index(CVAI)and blood glucose fluctuation,diabetic microvascular complications in patients with obesity and type 2 diabetes mellitus(T2DM).Methods A total of 120 patients with obesity and T2DM admitted to Tongde Hospital of Zhejiang Province were enrolled as study group between May 2020 and November 2022.According to presence or absence of microvascular complications,they were divided into complication group and non-complication group.A total of 100 patients with non obese T2DM during the same period were enrolled as control group.The serum adipokine Metrnl,CVAI and blood glu-cose in different groups were compared.The correlation between Metrnl and CVAI,blood glucose fluctuation,clinical in-dexes was analyzed.The relationship between Metrnl,CVAI,blood glucose fluctuation indexes and microvascular compli-cations was analyzed by logistic regression model.Results The body mass index and systolic blood pressure(SBP)were higher in study group than control group(P＜0.05).The course of disease was longer in complication group than non-complication group,and SBP was higher in complication group(P＜0.05).Metrnl,CVAI,mean standard deviation of blood glucose(SDBG),largest amplitude of glycemic excursion(LAGE)and postprandial glucose excursion(PPGE)were higher in study group than control group(P＜0.05),but difference in mean blood glucose(MBG)be-tween the two groups was not statistically significant(P＞0.05).Metrnl,CVAI,SDBG,LA GE and PPGE were higher in complication group than those of non-complication group(P＜0.05),but difference in MBG between the two groups was not statistically significant(P＞0.05).The level of serum Metrnl was positively correlated with CVAI,SDBG,LAGE and PPGE(r=0.511,0.442,0.485,0.477,P＜0.05).The results of logistic regression analysis showed that Metrnl,C VAI and LAGE were independent risk factors of microvascular complications in obese patients with T2DM(P＜0.05).Con-clusion Adipokine Metrnl and CVAI are increased,and blood glucose fluctuation is greater in obese patients with T2DM and microvascular complications.The above indexes can be applied as new markers of microvascular complications.
维普
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