Objective To explore the correlation between serum nutrient biomarkers and osteoarthritis in elder-ly patients.Methods A total of 607 elderly patients admitted to Beijing Jishuitan Hospital from February to March 2023 were selected.The patients were divided into osteoarthritis group and non-osteoarthritis group according to whether they had osteoarthritis or not.General data and serum nutrient biomarkers of total protein,albumin,globulin,calcium,phosphorus and potassium were collected.The correlation between serum nutrient biomarkers and osteoarthritis was ana-lyzed by logistic regression analysis.Results The level of serum total protein,albumin,globulin,phosphorus,sodium and chlorine were significantly higher than those in non-osteoarthritis group(P<0.05).Logistic regression analysis showed that serum potassium(OR=0.635,95%CI:0.420-0.960)and serum calcium(OR=0.025,95%CI:0.005-0.124)were correlated with the osteoarthritis.Conclusions Serum potassium and calcium are negatively cor-related with the osteoarthritis.