Changes of glucose metabolism in patients with digestive tumors under different inflammatory states and their relationship with hemoglobin and significance analysis
Objective To investigate the changes of glucose metabolism in patients with digestive tumors under different inflammatory states and analyze the relationship and significance with hemoglobin(Hb).Methods Retrospec-tive analysis was performed among 80 patients with digestive tumors in Huguosi Hospital of Traditional Chinese Medicine Affiliated to Beijing University of Traditional Chinese Medicine from February 2021 to February 2022.The C-reactive protein(CRP)level was tested by particle enhanced immunotransmission turbidimetric method,the blood glucose was tested by glucose oxidase method,and the glycocated hemoglobin(HbA1c)level was tested by ion exchange and high performance liquid chromatography method,conventional methods for detecting Hb levels,and the analysis and correla-tion were carried out.Results According to the reference value of normal CRP level in our hospital,the patients were divided into 26 cases of normal CRP level group(group A),42 cases of mild to moderate increase in CRP level group(group B)and 12 cases of severe increase in CRP level group(group C).According to the WHO standard of diabetes diagnosis with HbA1c＞6.5％,the patients were divided into normal group(41 cases),high group(21 cases)and con-firmed group(18 cases).According to different CRP levels,the patients were divided into group A,group B and group C.CRP in the three groups showed a gradual increase(P＜0.05),FPG in group A and group B showed a gradual in-crease,FPG in group C showed a downward trend(P＞0.05),and Hb in groups A,B and C showed a decrease(P＜0.05)with the increase of CRP.According to different HbA1c levels,the patients were divided into normal group,high group and confirmed diabetes group.FPG level of the three groups showed a gradual increase,but no statistical signifi-cance(P＞0.05),Hb level showed a gradual decrease(P＜0.05),CRP level showed a downward trend after the in-crease(P＜0.05).Pearson correlation analysis showed that CRP was negatively correlated with Hb level(r=-0.315,P＜0.01),FPG was positively correlated with Hb and HbA1c(r=0.0.524,0.4025,P＜0.01),and Hb was negatively correlated with HbA1 c(r=-0.824,P＜0.001).Conclusion Most patients with digestive tumors will have abnormal glucose metabolism,and inflammation and Hb levels change significantly with abnormal glucose metabolism.
Digestive system neoplasmsInflammationBlood glucoseHemoglobins
维普
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