Cardiac amyloidosis is a disease caused by the buildup of clumps of abnormally folded protein in the cardiac extracellular matrix.Cardiac amyloidosis was previously considered a rare disease which is frequent in eld-erly.There are likely to be misdiagnosed of cardiac amyloidosis in elderly patients whose symptoms lack specificity.With the development of diagnostic methods and the increased sensitivity of clinicians to disease symptoms,the inci-dence of patients diagnosed with cardiac amyloidosis has increased in recent years.Meanwhile,many various trials of specific amyloid drugs are obtaining promising results.The early and rapid diagnosis and therapy can prevent further amyloid deposition and further end-organ damage,thereby improving the prognosis of elderly patients with cardiac amyloidosis.Therefore,it is important for clinicians to better understand the characteristics,diagnosis and treatment of the elderly patients with cardiac amyloidosis.