Objective To explore the gut microbiota characteristics related to glucose variability(GV)in newly diagnosed elderly patients with type 2 diabetes(T2DM).Methods Forty newly diagnosed elderly patients with T2DM were included in the endocrinology outpatient department of Beijing Hospital from February 2023 to September 2023.They were grouped according to mean amplitude of glycemic excursions(MAGE)and coefficient of variation(CV),continuous glucose monitoring and recording of dietary habits during the monitoring period,analyzing differences in gut microbiota at different GV levels.Results Both grouping results indicated significant blood glucose variability in elderly newly diagnosed T2DM patients,with a high MAGE ratio of 70％and a high CV of 25％.Using CV thresholds corre-sponding to the HbA1c range was more advantageous in controlling variables and evaluating blood glucose variability at different levels of blood glucose control compared to MAGE.There was a positive correlation between spindle chain rod genus and fecal bacilli genus and two types of GV indicators;In the MAGE grouping study,there was a positive correla-tion between the levels of MAGE and the genera of Bacteroides,Ruminococcaceae,and Clostridia.Conclusions Elderly patients with newly diagnosed T2DM may exhibit significant glycemic fluctuations in the early stages of the disease.Gen-era such as Fusicatenibacteria,Faecalibacterium,Eubacterium_eligens_group,and Ruminococcaceae may influence gly-cemic fluctuations in elderly patients with T2DM.
维普
万方数据
