Objective To investigate the expression levels of serum CXC chemokine ligand 12(CXCL12)and vascular endothelial growth factor A(VEGF-A)proteins in the serum of elderly patients with osteoporosis(OP)and their correlation with sarcopenia.Methods A total of 192 elderly OP patients who visited Emergency General Hospital from June 2021 to January 2023 were collected as the study subjects,and according to whether they were complicated with sarcopenia,they were divided into sarcopenia group and non sarcopenia group.Enzyme linked immunosorbent assay(ELISA)was applied to detect the expression levels of serum CXCL12 and VEGF-A proteins;Pearson method was ap-plied to analyze the correlation between serum CXCL12,VEGF-A levels and limb skeletal muscle index(SMI)in pa-tients.Logistic regression was applied to analyze the influencing factors of sarcopenia in elderly OP patients,receiver op-erating characteristic(ROC)curve was applied to analyze the diagnostic efficacy of serum CXCL12 and VEGF-A protein levels in elderly OP patients with sarcopenia.Results The incidence of sarcopenia in 192 elderly OP patients was 36.98％(71/192).The serum levels of CXCL12 and VEGF-A in the sarcopenia group were lower than those in the non sarcopenia group(P＜0.05).Pearson analysis showed that serum CXCL12 and VEGF-A levels were positively correlated with SMI in elderly OP patients with sarcopenia(r=0.583,P＜0.001;r=0.643,P＜0.001).The percentage of pa-tients with age≥70 years old,body mass index(BMI)＜24 kg/m2,history of diabetes,and chronic kidney disease,systolic blood pressure(SBP)and diastolic blood pressure(DBP)in the myopenia group were higher than those in the non myopenia group(P＜0.05),the upper limb fat content,serum 25 hydroxy vitamin D3[25(OH)D3]level,calcium content,average bone mineral density of L1-4,and bone mineral density of neck of femur were lower than those in the non myopenia group(P＜0.05).The results of multivariate logistic regression analysis showed that age≥70 years old,history of diabetes,high SBP and DBP were all risk factors for elderly OP patients with myopenia(P＜0.05),high up-per limb fat content,serum 25(OH)D3,CXCL12,VEGF-A levels,calcium content,L1-4 average bone density,and neck of femur bone density were protective factors(P＜0.05).The combined diagnosis of serum CXCL12 and VEGF-A levels in elderly OP patients with sarcopenia had a higher AUC than their individual diagnosis(Z=2.554,P=0.011;Z=2.466,P=0.014).Conclusions The serum levels of CXCL12 and VEGF-A in elderly patients both can serve as diag-nostic indicators for elderly OP patients with sarcopenia,and the combination of the two has better diagnostic efficacy.
维普
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