Objective To analyse the effects of different thyroid puncture needles combined with different cyto-logical preparation methods on the effects of fine needle aspiration sampling of thyroid nodules,and search for the opti-mal mode of fine needle aspiration cytology of the thyroid.Methods Two hundred and forty patients who underwent ul-trasound-guided thyroid fine-needle aspiration cytology from June 2020 to August 2021 at the Affiliated Chuzhou Hospital of Anhui Medical University were selected.They were divided into 4 groups:syringe puncture+conventional smear cytol-ogy examination group,syringe puncture+liquid-based cytology examination group,suction biopsy needle puncture+conventional smear cytology examination group,and suction biopsy needle puncture+liquid-based cytology examination group,and compared the incidence of undiagnostic/unsatisfactory(sampling failure)in the cytological diagnostic reports of the patients among 4 groups,as well as the degree of puncture complications and puncture pain.Results(1)The difference in sampling results among 4 groups was statistically significant(P＜0.05);further analysis showed that the rate of sampling failure was lower in the syringe+liquid-based than in the syringe+routine smear group(P＜0.05),and the difference in the rate of sampling failure between the other groups was not statistically significant.(2)There was no statistically significant difference in the extraction results between the syringe group and the attraction biopsy needle group(x2=0.144,P=0.704);the extraction failure rate of the conventional smear group was higher than that of the liquid-based group(x2=5.192,P=0.023).(3)Stratified analysis according to nodal elasticity score:when the elastic-ity score=2,the failure rate of sampling in the syringe group was higher than that in the suction biopsy group(x2=5.10,P=0.024);when the elasticity score was＞2,the difference in the failure rate of sampling between the 2 types of perforating needles was not statistically significant(x2=1.3,P=0.254).(4)Stratified analysis according to nodal blood flow intensity:when blood flow intensity＞1,the routine smear group had a higher sampling failure rate than the liquid-based cytology group(P=0.006).(5)The difference in pain scores among the 4 groups was statistically signifi-cant(P=0.015),and analysis of the combined same puncture needle groups showed that the pain score in the syringe group was higher than that in the suction biopsy needle group(x2=3.165,P=0.002).(6)Complications of puncture:1 case of local haematoma and 1 case of hypotension occurred in the syringe+routine smear group,1 case of hypotension occurred in the attraction biopsy needle+routine smear group,and no complications occurred in the remaining 2 groups.Conclusions There is no overall difference in the sampling results between the syringe and the suction biopsy needle.Se-lecting puncture and sectioning methods based on the ultrasound report of thyroid nodules can improve the success rate.
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